Florfenicol Powder

Ingredients: Florfenicol

Appearance: White or light white powder

Pharmacological action

Pharmacodynamics

Florfenicol belong to the amphenicols broad-spectrum antibiotic,has a strong antimicrobial activity on the gram-positive bacterium, gram-negative bacterium and mycoplasma.Florfenicol is a kind of bacteriostat,combination with the ribosome 50S subunit,inhibit the bacteria protein synthesis.The antimicrobial activity of the florfenicol in vitro is similar or better than the chloramphenicol, thiamphenicol,the bacteria resistant to chloramphenicol which caused by acetylation,such as escherichia coli, klebsiella pneumonia may still sensitive to florfenicol. Pasteurella hemolytica, pasteurella multocida and actinobacillus pleuropneumoniae are highly sensitive to florfenicol.

Pharmacokinetics

After oral administration of florfenicol, absorption was very speed,about 1 hour can achieve treatment concentration in blood,1-3 hours peak plasma concentration.The bioavailability can achieve over 80%.The distribution of florfenicol in animal is very extensive, effectively traverse blood-brain barrier.The florfenicol technical mainly excrete in urine,less excrete in faeces.

Drug interactions

1.The action target of the macrolides and lincosamides is same with this product,all of them are combination with the ribosome 50S subunit, combination use produce the antagonism.

2.May antagonism the bactericidal activity of the penicillins and aminoglycosides,but do not demonstrated in animal body yet.

Indications:

Used to treat the bacteriosis of pig,chicken and fish which caused by sensitive bacteria.Such as, swine respiratory infections caused by pasteurella hemolytica, pasteurella multocida and pig pleurisy actinobacillus. Typhoid fever, paratyphoid, chicken cholera, pullorum disease, colibacillosis and so on which caused by salmonella;The fish bacterial septicemia, enteritis, red skin disease and son on which caused by fish pasteurella, vibrio, staphylococcus aureus, aeromonas hydrophila, gartner's bacillus and so on.

Usage and Dosage:

Calculated on this product

For oral administration,per KG weight,pig,chicken 0.2-0.3g.Twice a day, continuous use 3-5 day.

Mix feed:per KG weight,fish 0.1-0.15g.Once a day, continuous use 3-5 days.

Adverse drug reaction:

1.Use high dose has the immunosuppressive action

2.It has embryotoxicity, pregnancy and lactation livestock should be used with caution

Precautions:

1. Egg laying period is forbidden

2. Renal insufficiency livestock should reduce or extend interval time using medicine.

3. Vaccination period or immune function defect animals are forbidden.

Withdrawal Period:

Pig 20 days,Chicken 5 days,Fish 375 days.

Specification:10%

Packing:

Storage: Dry, sealing preservation

Valid Date: 2 years